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《医学前沿(英文)》 2017年 第11卷 第1期 页码 120-128 doi: 10.1007/s11684-017-0501-3
Norepinephrine transporter (NET) transfection leads to significant uptake of iodine-131-labeled metaiodobenzylguanidine (131I-MIBG) in non-neuroendocrine tumors. However, the use of 131I-MIBG is limited by its short retention time in target cells. To prolong the retention of 131I-MIBG in target cells, we infected hepatocarcinoma (HepG2) cells with Lentivirus-encoding human NET and vesicular monoamine transporter 2 (VMAT2) genes to obtain NET-expressing, NET-VMAT2-coexpressing, and negative-control cell lines. We evaluated the uptake and efflux of 131I-MIBG both in vitro and in vivo in mice bearing transfected tumors. NET-expressing and NET-VMAT2-coexpressing cells respectively showed 2.24 and 2.22 times higher 131I-MIBG uptake than controls. Two hours after removal of 131I-MIBG-containing medium, 25.4% efflux was observed in NET-VMAT2-coexpressing cells and 38.6% in NET-expressing cells. In vivo experiments were performed in nude mice bearing transfected tumors; results revealed that NET-VMAT2-coexpressing tumors had longer 131I-MIBG retention time than NET-expressing tumors. Meanwhile, NET-VMAT2-coexpressing and NET-expressing tumors displayed 0.54% and 0.19%, respectively, of the injected dose per gram of tissue 24 h after 131I-MIBG administration. Cotransfection of HepG2 cells with NET and VMAT2resulted in increased 131I-MIBG uptake and retention. However, the degree of increase was insufficient to be therapeutically effective in target cells.
关键词: norepinephrine transporter vesicular monoamine transporter 2 -MIBG gene therapy lentivirus vector
a novel K+ transporter gene in cotton
Yiru WANG, Juan XU, Mingcai ZHANG, Xiaoli TIAN, Zhaohu LI
《农业科学与工程前沿(英文)》 2018年 第5卷 第2期 页码 226-235 doi: 10.15302/J-FASE-2017170
Loss of monocarboxylate transporter 1 aggravates white matter injury after experimental subarachnoid
《医学前沿(英文)》 2021年 第15卷 第6期 页码 887-902 doi: 10.1007/s11684-021-0879-9
关键词: microRNAs monocarboxylate transporter 1 motor training subarachnoid hemorrhage white matter injury
Hui Wan,Yu Xia,Jianghua Li,Zhen Kang,Jingwen Zhou
《化学科学与工程前沿(英文)》 2017年 第11卷 第1期 页码 72-88 doi: 10.1007/s11705-016-1580-4
关键词: 2D-DIGE pqqB pyrroloquinoline quinone RNA-Seq Vitamin C
Expression and function of DMT1 without IRE in C6 cells mediated by recombinant adenovirus
Xixun DU*, Huamin XU*, Hong JIANG, Jun WANG, Lei WANG, Junxia XIE
《医学前沿(英文)》 2009年 第3卷 第1期 页码 67-71 doi: 10.1007/s11684-009-0010-0
关键词: divalent metal transporter 1 recombinant adenovirus homologous recombination iron
GAO Shihao, SUN Chenghui, ZHAO Xinqi, GAO Changquan
《化学科学与工程前沿(英文)》 2008年 第2卷 第1期 页码 80-84 doi: 10.1007/s11705-008-0017-0
关键词: 5-Amino-1 2 4-thiadiazol-3-yl 1 2-dichloroethane important intermediate 2-benzothiazolyl thioester temperature
Xiaohong LI, Wenying LI,
《化学科学与工程前沿(英文)》 2010年 第4卷 第2期 页码 142-146 doi: 10.1007/s11705-009-0233-2
关键词: desorption different TiO-AlOmixed physisorption ethylbenzene
Al2O3 and CeO2-promoted MgO sorbents for CO2 capture at moderate
Huimei Yu, Xiaoxing Wang, Zhu Shu, Mamoru Fujii, Chunshan Song
《化学科学与工程前沿(英文)》 2018年 第12卷 第1期 页码 83-93 doi: 10.1007/s11705-017-1691-6
以净零排放为目标的封存驱动型CO2提高采收率方法 Article
刘月亮, 芮振华
《工程(英文)》 2022年 第18卷 第11期 页码 79-87 doi: 10.1016/j.eng.2022.02.010
关键词: CO2 EOR CO2净排放量 二甲醚 封存驱动型CO2 EOR CO2封存
The stabilization effect of Al2O3 on unconventional Pb/SiO2 catalyst
《化学科学与工程前沿(英文)》 2023年 第17卷 第10期 页码 1423-1429 doi: 10.1007/s11705-023-2315-y
关键词: Pb/SiO2 Al2O3 propane dehydrogenation propene stability
Biodegradation of 2-methylisoborneol by bacteria enriched from biological activated carbon
Rongfang YUAN, Beihai ZHOU, Chunhong SHI, Liying YU, Chunlei ZHANG, Junnong GU
《环境科学与工程前沿(英文)》 2012年 第6卷 第5期 页码 701-710 doi: 10.1007/s11783-011-0367-6
关键词: 2-methylisoborneol (2-MIB) biodegradation 2-methylenebornane 2-methyl-2-bornane pseudo-first-order reaction
Encapsulation of 2-amino-2-methyl-1-propanol with tetraethyl orthosilicate for CO2 capture
Sidra Rama, Yan Zhang, Fideline Tchuenbou-Magaia, Yulong Ding, Yongliang Li
《化学科学与工程前沿(英文)》 2019年 第13卷 第4期 页码 672-683 doi: 10.1007/s11705-019-1856-6
关键词: carbon capture microencapsulated sorbents emulsion technique low temperature adsorption and absorption
Cu-doped Bi/Bi2WO6 catalysts for efficient N2 fixation by photocatalysis
《化学科学与工程前沿(英文)》 2023年 第17卷 第10期 页码 1412-1422 doi: 10.1007/s11705-023-2312-1
关键词: Bi2WO6 Cu doping work function photocatalytic N2 fixation charge separation
Fenton oxidation of 2,4- and 2,6-dinitrotoluene and acetone inhibition
HE Yiliang, ZHAO Bin, HUGHES Joseph B., HAN Sung Soo
《环境科学与工程前沿(英文)》 2008年 第2卷 第3期 页码 326-332 doi: 10.1007/s11783-008-0038-4
CO2 methanation and co-methanation of CO and CO2 over Mn-promoted Ni/Al2
Kechao Zhao,Zhenhua Li,Li Bian
《化学科学与工程前沿(英文)》 2016年 第10卷 第2期 页码 273-280 doi: 10.1007/s11705-016-1563-5
关键词: Mn promotion nickel catalysts CO2 methanation co-methanation of CO and CO2
标题 作者 时间 类型 操作
Cotransfecting norepinephrine transporter and vesicular monoamine transporter 2 genes for increased retention
null
期刊论文
a novel K+ transporter gene in cotton
Yiru WANG, Juan XU, Mingcai ZHANG, Xiaoli TIAN, Zhaohu LI
期刊论文
Loss of monocarboxylate transporter 1 aggravates white matter injury after experimental subarachnoid
期刊论文
Identification of transporter proteins for PQQ-secretion pathways by transcriptomics and proteomics analysis
Hui Wan,Yu Xia,Jianghua Li,Zhen Kang,Jingwen Zhou
期刊论文
Expression and function of DMT1 without IRE in C6 cells mediated by recombinant adenovirus
Xixun DU*, Huamin XU*, Hong JIANG, Jun WANG, Lei WANG, Junxia XIE
期刊论文
Improvement in the synthesis of 2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(Z)-methoxyiminoacetic acid 2-benzothiazolyl
GAO Shihao, SUN Chenghui, ZHAO Xinqi, GAO Changquan
期刊论文
Effect of TiO 2 loading on the activity of V/TiO 2 -Al 2 O 3 in the catalytic oxidehydrogenation of ethylbenzene
Xiaohong LI, Wenying LI,
期刊论文
Al2O3 and CeO2-promoted MgO sorbents for CO2 capture at moderate
Huimei Yu, Xiaoxing Wang, Zhu Shu, Mamoru Fujii, Chunshan Song
期刊论文
Biodegradation of 2-methylisoborneol by bacteria enriched from biological activated carbon
Rongfang YUAN, Beihai ZHOU, Chunhong SHI, Liying YU, Chunlei ZHANG, Junnong GU
期刊论文
Encapsulation of 2-amino-2-methyl-1-propanol with tetraethyl orthosilicate for CO2 capture
Sidra Rama, Yan Zhang, Fideline Tchuenbou-Magaia, Yulong Ding, Yongliang Li
期刊论文
Fenton oxidation of 2,4- and 2,6-dinitrotoluene and acetone inhibition
HE Yiliang, ZHAO Bin, HUGHES Joseph B., HAN Sung Soo
期刊论文